Relevant Review on Ursolic Acid
Summary: Studies have shown that Ursolic acid can inhibit fat accumulation and enhances muscle growth. It also acts to keep blood sugar levels in check. This helps in preventing cancer and other diseases.
The studies conducted on Ursolic acid and the skeletal muscle Akt activation has proved that Ursolic acid reduces diet-induced fat or obesity, white colored adipose tissue, fatty liver diseases and glucose intolerance. In the same way, persons who consumed large amounts of fatty diet containing ursolic acid put on less weight compared to persons that eat large fatty diet without any ursolic acid. In addition, persons consuming ursolic acid have smaller epidermal fat layers. These data suggest that ursolic acid reduce obesity. Ursolic acid also acts as an agent to counter the genetic response while fasting, that mediate muscle breakdown.
Details of Ursolic Acid
When Ursolic acid is consumed by individual at 0.4% up to 0.27% in the diet in weight, it is known to be capable of preventing muscles breakdown through genetic signalling which is the opposite to those which mediates muscle breakdown via fasting. It was capable of increasing skeletal muscles accrual by enhancing anabolic genes-transcription. The most notable is that being IGF-1. It does not appear to increase the IGF-1 expression within adipose tissues. This shows that this specific activity is only specific to the skeletal muscles. This anabolic effect depicts protein accrual as well as increasing the muscle cell size.
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Ursolic acid behaves like an inhibitor of an enzyme called the PTP1B enzyme. The PTP1B enzyme behaves as a negative regulator for the insulin reception and suppresses all its effects. It is a therapeutic agent in the treatment for high blood glucose within Type II Diabetes. The studies done about its IC50 value or concentration needed to prevent half of its active enzyme within the ranges of 3.6+ or -0.2μM, 3.08μM, and 3.9μM; repeatedly demonstrate potency. This inhibition of the Ursolic acid over the PTP1B extends up to other related enzymes like T-cell proteins tyrosine phosphatase or TCPTP, and src homology phosphatase-2 or SHP2.Ursolic acid is nearly two times as potent compared to its similar structured and regularly co-existing molecule called Corosolic Acid about IC50 7.2+/-0.8μ. The concentration of 50 to 100μM Ursolic acid can behave like insulin mimetic. It acts upon the receptor and bears no inherent impact at 10μM. However, studies show that acute blood glucose reduction with Ursolic Acid happened by taking injections in the range of 200mg/kg. This is likely the range to act upon an insulin receptor. Concentration as small as 1mcg/mL Ursolic Acid or 0.45uM might enhance the efficacy of the biologically relevant concentration of insulin within the body.
Lots of studies have been conducted with nontoxic dosage of ursolic acid. These studies show that, Ursolic acid even inhibits expression of the MMP9 and MMP2 with intermediates needed for the last stage of angiogenesis to new tissues. This inhibition of the vascularization has recently become known for all its anti-cancer and therapeutic potential since the new tumor cell requires blood flow as well as angiogenesis to survive. Ursolic acid also has lipophilic pentacyclic triterpenoid. This contributes to the waxy coats found on pear, apples, various other fruits, as well as many herbs, inclusive of certain folkloric herbal medicine for diabetes. Persons who have tries Ursolic acid give it a high rating, since this product really works well for all. You can try it out for some months and see where this Ursolic acid can take you. It is good for retaining body’s lean mass and helps you to shed some fat mass, and it lets you maintain your stamina. You will feel stronger than usual, but will not feel any heavier. You can see results with Ursolic acid fairly early itself. You begin to see actual results from around 5 weeks onwards. Hence, ursolic acid is very beneficial to persons of all age groups.
